Women's Corner
Women's Corner
A) With normal secondary sexual characters
B) Wth absent seconary sexual characters
C) With heterosexual develpment .
The most common causes (according to Kase) :
1. Ovarian failure whether normal or abnormal karyotype
2. Mullerian agenesis
3. AIS 4. Constitutional delay .
Normal secondary sexual characters (delayed menarche only) :
1. Imperforate hymen 2. Transverse vaginal septum
3. Vaginal agenesis without or without functioning uterus
4. Complete type of Androgen insensitivity syndrome
5. Persistent ovary syndrome and PCO 6. Consistutional delay of menarche
With heterosexual development :
1. Ovarian : PCO , virlizing ovarian tumors
2. Adrenal : Delayed CAH, Cushing syndrome and andogen secreting tumor
3. Certain cases of male pseudohermaphroditism e.g. 5 -reductase deficiency, absent MIF and incomplete AIS .
4. True hermaphroditism
Absent secondary sexual characters (sexual infantilism) :
Tall or normal Short Hypogonado- GnRh deficiency / Kallman syndrome Laurance Moon Biedl syndrome tropic Weight loss and excercise Levi lorain syndrome Hyperprolactinemia Hypothyroidism CNS tumor Hypergonado- Gonadal agensis (XX or XY [Swyer]) Turner tropic Mixed gonadal dysgenesis (rarely) Mixed gonadal dysgenesis Ovarian failure (radio or chemotherapy or Galactose defeciency) True hermaphroditism
dr. Hisham Al-Inany Lecturer in Obstetrics and Gynecology Department, Cairo University, Egypt Dr. Amr Hussein Lecturer in Obstetrics and Gynecology Department, Cairo University, Egypt