Men's Health - Male Infertility
HYPOTHALAMIC-PITUITATARY-GONADAL AXIS
| HYPOTHALAMIC-PITUITATARY-GONADAL AXIS Neurotransmitters and neuropeptides from higher CNS centers regulate episodic release of gonadotrophin releasing hormone (GnRH) from the hypothalamus. · GnRH regulate the release of LH & FSH from the pituitary. · LH stimulate the synthesis of testosterone (T) from the Leydig cells of the testis. (T) is metabolized in the peripheral tissues to estradiol (2). (T) & E2 exhibit negative feedback control on the release of GnRH & LH. · FSH works on Sertoli cells within the seminiferous tubules leading to the secretion of: Inhibin which causes negative feed back control on FSH release. Androgen binding protein (ABP) which binds testosterone and transports it in a very high concentration into the seminiferous tubules to stimulate spermatogenesis. |
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Copyrights Dr. Hussein Ghanem 1999 All Rights
Reserved
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جميع حقوق الطبع والنشر محفوظة للدكتور حسين غانم
لعام 1999
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Page written & discussion moderated by:
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Professor of Andrology, Cairo University
Formerly: Fellow in Male Reproductive Medicine and Surgery, Baylor College of Medicine, Houston, Texas, USA Formerly: Fellow in Male Sexual Function, Reproduction, and Surgery, University of Iowa Hospitals & Clinics, Iowa City, Iowa, USA |
| Telephone: +(202) 761 3334 |
| E-mail: ghanem@family-clinics.com |
| Address: 139 (A) Al-Tahrir Street, Dokki, Cairo, Egypt |
