Women's Corner - Syndromes
Polycystic Ovary Syndrome
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By: Abdel-Maguid Ismail Ramzy, M.D.
Ass. Prof. Of Obstetrics and Gynaecology, Cairo University. Consultant R |
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What went wrong?
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| Disruption of this rhythm may lead to interruption of ovulation and hormonal imbalance. In case of PCOS the disruption is expressed in the form of excessive secretion of LH from the pituitary gland as a result of erroneous messages coming from the hypothalamus. Excess LH leads to overproduction of androgen from the ovarian stromal tissues. In addition, the disruption leads to insufficient or dysrhthmic FSH production leading to improper development and maturation of the growing oocyte. If this continues, the ovary will be filled with multiple small cysts from the follicles that failed to maturate and develop. However these small cysts are capable of estrogen production that collectively may amount to high levels. This charactarises the syndrome of PCOS where there are excessive amounts of both estrogens and androgens circulating within the body. Moreover the free bioavailable portion of these hormones is increased as well as a result of low sex hormone binding globulin (SHBG). Endometrial stimulation by the high levels of estrogen (unopposed by effect of progesterone) results in endometrial hyperplasia (thickening) causing heavy and irregular bleeding. If the condition remain unchecked over the years, this may result in endometrial carcinoma. Excessive prolonged androgen production as well results in skin disorders such as oily complexion, acne, and hirsutism. |
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Copyrights Dr. Abel Maguid Ramzy 2000 All Rights
Reserved
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2000 جميع حقوق الطبع والنشر محفوظة للدكتور عبد
المجيد رمزي لعام
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THIS IS THE RIGHT PLACE TO START!!!
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This page is moderated by:
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| dr. Abdel Maguid Ramzy |
| Prof. of OB. GYN., Cairo University, EGYPT |
| valerie Ozsu |
| Certified Nurse-Midwife, USA |